Research

Programmable gene synthesis has revolutionized biomolecular engineering. Despite recent advancements in microchip-based oligonucleotides synthesis, synthesis errors remain a significant challenge. We aim to establish a platform for generating high fidelity, highly complex gene libraries that enhance protein functionality and enable discovery of new biomolecules. 

Deciphering protein identities at single-molecule resolution in a highly parallel manner is a holy grail in the field of bioengineering. However, previous approaches have been limited by low throughput. We aim to develop a technology capable of protein fingerprinting at high throughput.

Nucleic acids can be repurposed for non-genomic applications. For example, binary digital information can be encoded into quaternary DNA sequences, and arbitrary structures can be fabricated at the nanometer scale.  We aim to develop unique molecular tools for bioengineering through DNA nanotechnology

Force plays a crucial role in biological systems. By deciphering molecular interactions, the mechanisms governing force-induced transduction and regulation (e.g., immune cell activation) can be decoded. We aim to increase the throughput of single-molecule analysis to facilitate systematic studies.